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在fusobacterial与结直肠癌相关物种共同聚合中的菌株特异性

Avery V Robinson¹, Emma Allen-Vercoe¹

¹University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada.

|July 9, 2023

概括

富索细菌核亚种. 动物与与结直肠癌 (CRC) 相关的几种物种强烈联合聚合,可能促进生物膜形成和疾病进展.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
在瘤学瘤学.

背景情况:

结肠直肠癌 (CRC) 是一个重要的全球健康问题.
肠道微生物组在CRC的发展和进展中起着至关重要的作用.
富索细菌核亚种. 动物因其与CRC的关联而越来越受到认可.

研究的目的:

为了研究Fusobacterium nucleatum亚种之间的共同聚合相互作用. 动物和其他与结直肠癌相关的物种.
为了确定这些相互作用是否是菌株特异性的.
探索这些相互作用在生物膜形成和CRC病变发生中的潜在作用.

主要方法:

通过测量细菌菌株共同化后的光密度变化来量化同聚合.
评估了F. nucleatum亚种之间的相互作用. 动物和来自CRC活检衍生的社区的菌株.
额外的相互作用与来自其他人类胃肠道样本的菌株进行了测试.

主要成果:

发现同聚合模式高度针对菌株的特异性.
F.核子亚种核子亚种动物体表现出与Campylobacter concisus,Gemella spp.,Hungatella hathewayi和Parvimonas micra.的强烈联合聚合.
这些共同聚集的物种都与结直肠癌有关.

结论:

在F. nucleatum亚种之间共同聚合. 动物和CRC相关物种可能会在结肠病变上促进生物膜的形成.
结肠生物膜的形成与结肠直肠癌的促进和进展有关.
这些发现突出了一个潜在的机制,F. nucleatum亚种. 动物有助于CRC的病变.

关键词:

协同聚合协同聚合协同聚合结肠直肠癌是一种癌症.杆菌核酸 (Fusobacterium nucleatum) 是一种细菌.应变水平的变化.

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