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在患有阿尔多斯特产生腺瘤的患者中,与高胆血症相关的长期术后的低阿尔多斯特性腺瘤
Norio Wada1, Shuhei Baba1, Hajime Sugawara1
1Department of Diabetes and Endocrinology, Sapporo City General Hospital, Sapporo 060-8604, Japan.
Endocrine journal
|July 9, 2023
概括
长期的低阿尔多斯特 (PPHA) 影响15.5%的阿尔多斯特产生腺瘤 (APA) 的上腺切除术后的患者. 患有功能下降的老年患者更容易患PPHA和随后的高胆固醇血症.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术瘤学手术瘤学
背景情况:
- 阿尔多斯特生成腺瘤 (APA) 是一次性阿尔多斯特的常见原因.
- 上腺切除术是APA的标准治疗方法,但有些患者在手术后会出现高胆固醇血症.
- 经手术后的低固醇症 (PPHA) 被怀疑是APA上腺切除术后高血症的原因.
研究的目的:
- 确定经上腺切除术后患有APA的患者中长期术后低质素 (PPHA) 的频率和特征.
- 调查PPHA与患者人口统计,功能和术后高血症之间的关联.
主要方法:
- 在上腺切除术后很长时间研究了58名APA患者,使用化学发光酶免疫检测 (CLEIA) 测量了血中阿尔多素度 (PAC).
- 通过CLEIA与放射性免疫试验 (RIA) 测量的PAC值进行比较.
- 分析了患者的特征,包括年龄,估计的淋巴细胞过率 (eGFR) 和血清水平.
主要成果:
- 15.5%的患者使用CLEIA表现出无法测量的PAC (<4.0 pg/mL),表明PPHA.
- 患有PPHA的患者年龄较大 (61.3岁与50.5岁相比),并且具有较低的eGFR (60.3岁与82.3毫升/分钟/1.73米2).
- 在PPHA组中,术后高胆固醇血的发病率明显较高 (55.6%与8.2%相比).
结论:
- 上腺切除术后的一小部分患有APA的患者可能会经历无法测量的PAC,这表明PPHA.
- 高龄和功能受损是APA上腺切除术后发展PPHA的危险因素.
- PPHA与手术后高胆固醇血的风险增加有关.
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