测试酒精使用障碍的药物治疗方法与暗示暴露范式:人类实验室试验方法学的系统审查和定量综合
Lindsay R Meredith1, Elizabeth M Burnette2, Steven J Nieto1
1Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Alcohol, clinical & experimental research
|July 9, 2023
概括
药物可以减少对酒精的渴望和对酒精暗示的反应,有助于开发用于酒精使用障碍 (AUD) 的治疗方法. 本综述综合了试验数据,以改善AUD药物治疗查的暗示暴露范式.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 酒精暗示暴露是测试新药用于酒精使用障碍 (AUD) 的标准方法.
- 目前的研究表明,暗示暴露研究设计和结果报告的变化.
- 标准化这些方法对于有效的药物治疗开发至关重要.
研究的目的:
- 量化合成方法,估计药物对渴望和对酒精暗示的心理生理反应的影响大小.
- 确定趋势并提供建议,以优化AUD药物治疗研究中的暗示暴露范式.
主要方法:
- 通过PubMed.Med识别的36个随机试验 (1640名参与者) 的系统审查和定量合成.
- 数据提取包括研究特征,暗示暴露范式 (体内,视觉,音频) 和渴望/心理生理学结果.
- 对15种药物的渴望和心理生理学措施计算了效果大小 (科恩的d).
主要成果:
- 与安慰剂相比,八种药物显示在减少提示诱导的渴望方面具有小到中等效果 (科恩的d: 0.24-0.64).
- 从28项试验中总共合成了63种效果大小,重点关注15种药物.
- 大多数研究报告了生物性别,平均有71%的男性参与者.
结论:
- 针对酒精暗示反应的药物在治疗AUD方面表现有前途.
- 建议对暗示暴露范式和结果报告进行标准化,以加强药物治疗的发展.
- 进一步的研究应该调查降低暗示反应性和AUD中的临床结果之间的联系.
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