丸激素替代疗法是否会增加前列腺癌患者在积极监测下转换治疗的风险?
Jorge Daza1, Ali Ahmad1, Usma Shabir1
1Department of Urology, Roswell Park Cancer Institute, Buffalo, NY.
Urologic oncology
|July 9, 2023
概括
替代疗法 (TRT) 没有增加治疗转换的风险在男性局部性前列腺癌在主动监测 (AS). 这一发现支持对接受TRT的合格患者的持续监测.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 主动监测 (AS) 是局部性前列腺癌 (CaP) 的管理策略.
- 替代疗法 (TRT) 有时用于AS的CaP男性,但其对癌症进展的影响仍在争论中.
研究的目的:
- 评估TRT对治疗转换和无治疗生存 (TFS) 的影响,在局部化CaP患者中与AS一起管理.
主要方法:
- 一个CAP数据库的回顾性审查.
- 倾向性得分匹配 (1:3) 来比较AS患者与TRT与AS患者没有TRT.
- 卡普兰-梅尔分析TFS和多变量考克斯回归治疗相关变量.
主要成果:
- 接受TRT的24名患者与不接受TRT的72名患者进行了匹配.
- 两组之间对治疗转换 (24%对21%,P=1.00) 或TFS (日志排名P=0.87) 没有显著差异.
- 前列腺特异性抗原 (PSA) 密度是与TFS相关的唯一变量 (HR1.08,P=0.001).
结论:
- 在本匹配的AS局部性前列腺癌患者队列中,TRT与治疗转换的风险增加无关.
- 这些发现表明,在积极监测下,对于局部化CaP的男性,可以安全地考虑TRT.
相关概念视频
Disorders of the Male Reproductive System
474
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
474
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148


