超三糖血症-腰部表型与昼夜综合征风险之间的关联:一个纵向队列研究
Li-Kun Hu1, Yu-Hong Liu1, Kun Yang1
1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmenWai, Fengtai District, Beijing, 100069, China.
Hormones (Athens, Greece)
|July 9, 2023
概括
超高甘油血症腰部表型,以增加腰围和高甘油三水平为特征,与患有昼夜综合征 (CircS) 的风险更高有关. 这种关联即使在中国成年人的表型随着时间的推移而发生变化时也是如此.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征研究 代谢综合征研究
- 时间生物学与健康
背景情况:
- 循环节综合征 (CircS) 正成为心脏代谢风险的新型预测因素.
- 过高甘油血症腰部表型 (HW) 是一种已知的代谢功能障碍的指标.
- 了解HW和CircS之间的相互作用对于中国的公共卫生至关重要.
研究的目的:
- 调查超高甘油血症腰部表型及其动态变化与CircS风险之间的关联.
- 通过使用纵向数据,在大量中国人口中分析这些关系.
- 为了确定预测CircS发展的HW变化的特定模式.
主要方法:
- 这是一项采用中国健康与退休纵向研究 (CHARLS) 数据 (2011-2015) 的两阶段研究.
- 使用多变量逻辑回归和Cox比例危险模型进行横截面和纵向分析.
- 基于正常/扩大腰围 (WC) 和正常/高甘油三水平 (TG) 的CircS风险评估,包括动态变化.
主要成果:
- 与正常的WC和TG (NWNT) 相比,扩大的WC和高TG水平 (EWHT) 显著增加了CircS风险 (HR 3.87).
- 纵向分析显示,稳定的EWHT风险增加了9.97倍,而那些过渡到EWHT的风险增加了116.07倍.
- 亚组分析证实了这些关联跨越不同的人口统计和生活方式因素.
结论:
- 过高甘油血症腰部表型是中国成年人发展昼夜综合征的重要危险因素.
- 超高甘油血症-腰部表型的动态状态,特别是其发展或持久性,强烈预测CircS风险.
- 这些发现强调了监测WC和TG水平对于心脏代谢风险评估和CircS预防的重要性.
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