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相关概念视频

Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

2.4K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
2.4K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

1.2K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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相关实验视频

Updated: Jul 24, 2025

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

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在脏组织中的空间转录学.

Arti M Raghubar1,2,3,4,5, Joanna Crawford5, Kahli Jones5,6

  • 1Kidney Health Service, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.

Methods in molecular biology (Clifton, N.J.)
|July 9, 2023
PubMed
概括
此摘要是机器生成的。

空间转录组测序 (ST-seq) 通过结合组织学和RNA测序来绘制完整组织内的基因表达. 这项研究详细介绍了将ST-seq应用于新鲜冷的脏组织的协议,并保留了空间上下文.

关键词:
脏 - 脏 - 脏空间转录组学 空间转录组学视觉空间基因表达的表达视觉空间组织优化视觉空间组织优化

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相关实验视频

Last Updated: Jul 24, 2025

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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科学领域:

  • 分子生物学分子生物学
  • 基因组学就是基因组学.
  • 历史学 历史学 历史学

背景情况:

  • 空间转录组测序 (ST-seq) 提供了一种独特的方法来分析组织空间架构中的基因表达.
  • 像批量和单细胞RNA测序等传统方法缺乏空间分辨率.
  • 将组织学与RNA测序相结合,为基因表达数据提供了形态上下文.

研究的目的:

  • 为新鲜冷的脏组织应用ST-seq提供详细的协议.
  • 为了证明ST-seq在鉴定脏组织结构和基因表达中的实用性.
  • 优化Visium空间组织优化 (TO) 和Visium空间基因表达 (GEx) 协议的样.

主要方法:

  • ST-seq涉及从放置在带有oligo-dT斑点 (ST斑点) 的专用幻灯片上的组织部分捕获转录组.
  • 每个被捕获的转录组都会收到一个与其在组织上的位置相对应的空间条形码.
  • 测序数据与血素和素 (H&E) 染色图像对齐,用于空间上下文.

主要成果:

  • 使用ST-seq.成功地对小鼠和人类脏组织进行了表征.
  • 详细描述Visium空间TO和GEx协议,应用于新鲜冷的脏组织.
  • 综合基因表达数据与组织形态学的演示.

结论:

  • ST-seq是一种强大的方法,用于了解组织组织和基因表达模式.
  • 描述的协议允许对脏组织进行详细的空间分析.
  • 这种方法增强了对其本土环境中的组织特异性基因表达的理解.