炎症标志物的转录水平与第一发精神分裂症的短期大脑结构变化有关
Long-Biao Cui1,2,3,4, Xian-Yang Wang5, Yu-Fei Fu5
1Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. lbcui@fmmu.edu.cn.
BMC medicine
|July 9, 2023
概括
炎症与早期精神分裂症中的大脑结构变化有关,特别是皮质稀薄. 这表明免疫力在病情中起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 炎症是精神分裂症病理学的可疑因素,可能导致神经元损伤.
- 神经成像显示了精神分裂症患者的纵向大脑变化,但其与炎症的联系尚不清楚.
- 这项研究调查了早期精神分裂症中大脑结构变化和炎症标志物之间的关系.
研究的目的:
- 为了将大脑的结构变化与第一发精神分裂症炎症标志物的转录特征相关联.
- 探索精神分裂症患者大脑结构变化,外周炎症和临床症状/认知功能之间的关联.
主要方法:
- 包括38名第一发精神分裂症患者和51名健康对照.
- 在基线和随访 (2-6个月) 时,用于大脑结构分析 (基于表面的形态分析) 的高分辨率MRI.
- 大脑结构变化与免疫细胞基因组表达和外周炎症标志物的相关性,以及行为和认知评估.
主要成果:
- 精神分裂症患者在左额叶皮层表现出加速的皮质稀释和增加的皮体积.
- 皮层厚度的变化与患者的单细胞转录水平相关 (r=0.54,p<0.01).
- 在患者中,左上额叶叶皮层厚度的变化与认知功能 (数字跨度向后测试) 有正相关.
结论:
- 第一次精神分裂症患者表现出与认知障碍相关的区域大脑结构变化.
- 在早期精神分裂症中,炎症可能对皮质稀释有显著的贡献.
- 免疫-大脑-行为相互作用在精神分裂症的发病过程中至关重要.
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