急性-慢性肝衰竭的定义,诊断和流行病学
Ruben Hernaez1,2,3, Hai Li4, Richard Moreau5,6,7
1Section of Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center, TX Center, Houston, Texas, USA.
概括
急性至慢性肝衰竭 (ACLF) 的定义在全球范围内有所不同,这影响了患者的鉴定和风险评估. 本综述比较了东方和西方对ACLF的看法,强调了患者群体和器官衰竭标准的差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
背景情况:
- 急性至慢性肝衰竭 (ACLF) 是慢性肝病或肝硬化患者的严重疾病,短期死亡率高.
- 目前对ACLF的定义在不同地理区域之间有很大差异.
研究的目的:
- 从东方和西方的角度审查和比较ACLF的定义.
- 分析不同定义中使用的基础患者群体和器官衰竭标准的变化.
- 讨论各种ACLF定义的临床实用性.
主要方法:
- 对现有文献和共识指南进行叙述性审查.
- 对主要肝病学协会提出的定义进行比较分析.
- 检查与ACLF患病率和结果有关的流行病学数据.
主要成果:
- 东方 (例如,亚太肝脏研究协会) 和西方 (例如,欧洲肝脏研究协会,北美肝脏疾病研究联盟) 的ACLF定义之间存在显著差异.
- 变化包括考虑的特定患者群体和定义器官衰竭的标准.
- 每个定义都具有不同的临床实用性,从基础概念到数据驱动的标准和临床风险评估工具.
结论:
- 在全球范围内,ACLF的定义没有标准化,这导致了患者鉴定和管理的潜在差异.
- 了解ACLF定义的区域差异对于准确的诊断和有效的治疗策略至关重要.
- 需要进一步协调或明确划分每个定义的实用性,以改善ACLF患者的治疗结果.
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