胰岛素抵抗概率得分和发生心血管疾病的概率得分
Judy Z Louie1, Dov Shiffman1, Michael J McPhaul1
1Endocrine Division, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, USA.
Journal of internal medicine
|July 10, 2023
概括
胰岛素抵抗 (IR) 的高概率显著增加了老年人心血管疾病 (CVD) 的风险. 评估IR可能对预防心血管疾病在这个人群中至关重要.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 胰岛素抵抗 (IR) 是心血管疾病 (CVD) 的已知危险因素.
- 目前用于评估IR的方法,如胰岛素免疫检测,具有可变性问题.
- 在老年人群中对IR的研究有限,这阻碍了其在心血管疾病预防中的使用.
研究的目的:
- 通过质谱测定测定的胰岛素抵抗概率[p(IR) 和老年人队列中心血管疾病发病率之间的关联.
主要方法:
- 从MPP研究中分析了一组3645名老年参与者 (平均年龄68岁).
- 排除了先前患有心血管疾病或糖尿病的参与者.
- 随访时间为13.3年,观察发生的心血管疾病事件.
主要成果:
- 极高的IR概率[p(IR>80%]与51%的发生性心血管疾病风险增加有关 (HR=1.51).
- 高的p(IR) 也与心血管疾病或所有原因死亡率增加43%的风险相关 (HR=1.43).
- 这些关联在调整多个心血管风险因素后仍然显著.
结论:
- 胰岛素抵抗的可能性增加与老年人患心血管疾病的风险大大增加有关.
- 这些发现表明,IR评估可以成为针对老年人心血管疾病预防策略的宝贵工具.
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