在注射布罗卢齐祖马布 (brolucizumab) 治疗外泄性与年龄相关的黄斑变性后,未注射的对侧眼的变化
Paolo Mora1, Carlo Bellucci1, Lorenzo M Radice1
1Ophthalmology Unit, University Hospital of Parma, Parma, Italy.
European journal of ophthalmology
|July 10, 2023
概括
针对新血管与年龄相关的黄斑变性 (nAMD) 在一只眼睛内注射布罗卢齐祖马布,导致对侧,未注射的眼睛的黄斑胀减少. 这种效应与剂量和时间有关,这表明布罗卢齐祖马布的系统性影响.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 内抗血管内皮生长因子 (VEGF) 疗法是标准的治疗方法.
- 以前的抗VEGF药物已经显示出副作用,但对布罗卢齐祖马布的证据有限.
研究的目的:
- 描述一只眼睛内静脉注射布罗卢齐祖马布对患有nAMD的患者逆侧眼中的黄斑的作用.
主要方法:
- 一个双边nAMD患者的病例报告最初接受了bevacizumab和aflibercept的治疗.
- 治疗包括白内障手术和甲植入物.
- 静脉内勃鲁西祖马布 (brolucizumab) 给右眼,在两只眼睛中监测中央黄斑厚度 (CMT) 的变化.
主要成果:
- 在右眼中注射静脉内苏zumab导致CMT在治疗的右眼和对面的,未注射的左眼显著减少.
- 在右眼中第二次注射布罗卢齐祖马布后,CMT在两只眼睛中再次下降.
- 副作用似乎与剂量和时间有关.
结论:
- 这种情况表明,在nAMD患者中brolucizumab的潜在副作用.
- 观察到的效果依赖于剂量和时间,类似于其他抗VEGF药物.
- 需要进一步的研究,以了解这种反边反应的机制和临床影响.
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