有JAK2/STAT突变的急性髓性白血病与PD-L1上调相关
Jiani Chai1, Jui Choudhuri1, Qing Wang1
1Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
Leukemia & lymphoma
|July 10, 2023
概括
编程细胞死亡联体-1 (PD-L1) 在急性髓性白血病 (AML) 中具有JAK2/STAT突变时被上调. 这表明JAK/STAT突变的AML可能会对免疫检查点抑制剂产生反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 编程细胞死亡配体-1 (PD-L1) 的过度表达,一种免疫检查点蛋白,在固体瘤中很常见,但在急性髓性白血病 (AML) 中没有得到充分的研究.
- 已知JAK/STAT通路在临床前模型中增强PD-L1表达.
研究的目的:
- 在急性髓性白血病 (AML) 患者中研究PD-L1表达模式,患者在JAK2/STAT通路中具有激活突变.
- 评估JAK/STAT通路激活和PD-L1在AML中的表达之间的相关性.
主要方法:
- 分析了来自有或没有JAK2/STAT激活突变的AML患者的活检.
- 通过免疫组织化学染色来评估PD-L1表达.
- 使用综合阳性得分 (CPS) 系统量化PD-L1表达.
- 评估了酸化STAT3 (p-STAT3) 表达的情况.
主要成果:
- 与野生型对照组相比,患有JAK2/STAT突变的AML患者的PD-L1表达显著上调.
- 患有瘤JAK2激活的患者显示显著过度表达酸化STAT3.
- 在p-STAT3表达和PD-L1水平之间观察到正相关性.
结论:
- 综合阳性评分 (CPS) 系统可以作为在白血病中PD-L1表达的定量衡量.
- 具有JAK2/STAT突变的急性髓性白血病 (AML) 代表了涉及免疫检查点抑制剂的试验的潜在患者群体.
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