福科斯通过促进与阿克尔曼西亚相关的酸代谢促进肠干细胞介导的肠上皮细胞发育
Caihan Duan, Junhao Wu, Zhe Wang1
1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gut microbes
|July 10, 2023
概括
糖补充剂通过增强与阿克尔曼西亚有关的酸代谢来促进肠道干细胞 (ISC) 干细胞和上皮细胞的发育. 这种益生菌效应支持肠道平衡,并提供治疗潜力.
科学领域:
- 胃肠道学和微生物学
- 干细胞生物学 干细胞生物学
- 代谢学 代谢学 代谢学
背景情况:
- 肠干细胞 (ISC) 对于肠表皮的循环至关重要.
- 肠道微生物群及其代谢物对ISC干性的影响尚未完全理解.
- 糖在宿主微生物相互作用中的作用及其对ISC干性的特定影响需要澄清.
研究的目的:
- 为了研究糖对ISC介导的肠上皮细胞 (IEC) 发育的影响.
- 探索涉及肠道微生物群及其代谢物的潜在机制.
主要方法:
- 给小鼠注射Fucose,然后对ISC,IEC,肠道微生物 (16SrDNA测序) 和代谢物 (代谢物) 进行分析.
- 实验室内研究涉及带有糖的细菌培养和分离的小鼠乳腺密室用于有机体培养.
- 通过Wnt信号通路分析和Gpr41/Gpr43依赖性来评估机制.
主要成果:
- 福科斯的使用加快了ISC的增殖和分泌系的分化,而这种效应被抗生素消除了.
- 富可糖改变了肠道微生物的组成,显著增加了阿克尔曼西亚和酸的代谢.
- 由Akkermansia muciniphila发酵产生的propionic酸通过Gpr41/Gpr43激活了Wnt信号通路,增强了ISC茎度和有机体发育.
结论:
- 福可斯通过促进与阿克尔曼西亚有关的酸代谢来加速ISC介导的肠上皮细胞发育.
- 糖充当益生菌,通过微生物和代谢调节增强肠道平衡.
- 这些发现凸显了糖在促进肠道健康方面的潜在治疗应用.
相关概念视频
Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
Adult Stem Cells
30.3K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
30.3K
Microvilli
6.2K
Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
6.2K
Glucose Absorption Into the Small Intestine
31.8K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.8K


