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针对乳腺癌中的寡头转移的转移导向疗法

Toshiyuki Ishiba¹, Ikuno Nishibuchi², Fumikata Hara³

¹Department of Breast Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

Japanese journal of clinical oncology

|July 10, 2023

概括

在针对性治疗方面,正在研究局部癌症和广泛转移之间的一种状态 - - 寡度转移. 虽然有前途,但对乳腺癌的转移导向疗法需要进一步的前性试验来证明有效性.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
癌症转移癌症转移

背景情况:

氧基转移描述了局部癌症和广泛转移之间的中间疾病状态.
对寡头转移的定义有所不同,2020年的共识将其定义为1-5种可治疗的转移性病变.
转移导向治疗的病变发生和最佳患者选择尚不清楚.

研究的目的:

审查目前对乳腺癌转移导向疗法的理解和证据.
突出需要进行前性研究,以证实像立体性身体辐射疗法这样的治疗方法的疗效.

主要方法:

对转移导向治疗小卵性乳腺癌的回顾性研究和II期试验的审查.
讨论既有和新兴的疗法,包括手术,射频剥离和立体性身体辐射疗法.

主要成果:

追溯数据表明,转移导向疗法的潜在生存益处.
第二阶段试验显示,随着体内立体辐射疗法的高局部控制和整体生存率.
目前的证据主要基于追溯数据,前性验证有限.

结论:

以转移为导向的疗法,包括立体性身体辐射疗法,被认为是安全的,并在国际上用于小转移.
目前正在进行前性临床试验,以确定转移导向治疗乳腺癌小转移的疗效.
进一步的研究至关重要,以确定哪些患者从这些向治疗中获益最多.

关键词:

乳腺癌乳腺癌乳腺癌乳房外科手术乳房外科手术有机瘤芽症.辐射瘤学辐射瘤学放射学-PET的使用

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