在年轻人中使用基于voxel的形态测量来识别对逆境有弹性的结构性大脑标志物
Harriet Cornwell1, Nicola Toschi2,3, Catherine Hamilton-Giachritsis1
1Department of Psychology, University of Bath, Bath, UK.
Development and psychopathology
|July 10, 2023
概括
青年的弹性与大脑结构有关,特别是前额区域的灰质体积. 这项研究使用连续弹性得分来揭示青少年大脑发育中的神经生物学相关性和性别差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 脑部成像 脑部成像
背景情况:
- 青少年的性越来越被认可,但缺乏一致的操作化.
- 现有的定义通常依赖于狭窄的标准,阻碍神经生物学研究.
- 需要采用数据驱动的方法来探索青少年弹性的神经生物学基础.
研究的目的:
- 调查数据驱动的,持续测量性和青年的大脑结构之间的关联.
- 为了确定与弹性相关的特定大脑区域 (灰质体积).
- 为了检查弹性神经生物学中的潜在的性别差异.
主要方法:
- 利用了来自FemNAT-CD研究的298名青少年 (9-18岁) 的结构性MRI数据.
- 使用基于voxel的形态测量 (VBM) 与SPM12用于脑成像分析.
- 根据逆境暴露和精神病理学计算的持续性得分.
主要成果:
- 在右下额头和中额头回旋中发现弹性得分和灰质体积 (GMV) 之间的正相关性.
- 在中和中前陀螺中发现了显著的性与弹性相互作用.
- 弹性与执行功能,情绪调节和注意力至关重要的大脑区域有关.
结论:
- 青少年的弹性具有神经生物学基础,与特定的灰质体积有关.
- 研究结果强调了前脑区域在弹性方面的作用.
- 有证据表明,青少年恢复力的神经生物学基础上存在性别差异.
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