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乳酸杆菌酸性的超级潜水剂通过上调结肠SERT表达来缓解骨质疏松症
Jianhua Zhai1, Siyuan Sun2, Jing Cheng3
1Department of Emergency, Tianjin Medical University General Hospital, Tianjin, China.
Future microbiology
|July 10, 2023
概括
乳杆菌酸性超 (LAS) 可能通过增加血清素载体 (SERT) 表达来治疗骨质疏松症. 在严重骨质疏松症患者中发现了较低的便LA水平,与骨矿物质密度 (BMD) 降低相关.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 骨质疏松症 (OP) 是一种以低骨矿物密度 (BMD) 为特征的疾病.
- 肠道微生物组,包括Lactobacillus acidophilus (LA),可能会影响骨健康.
- 在肠道对骨质疏松症的影响中,血清素载体 (SERT) 的作用尚未完全理解.
研究的目的:
- 为了研究Lactobacillus acidophilus supernatant (LAS) 的抗骨质疏松作用.
- 为了确定血清素载体 (SERT) 在结肠上皮细胞中的参与LAS的抗骨质疏松作用.
- 探索便LA丰富度,BMD和骨质疏松症严重程度之间的相关性.
主要方法:
- 在患有骨质疏松症的患者中评估便LA丰度和BMD.
- 给小鼠进行LAS,以评估其对老年骨质疏松症的影响.
- 在体外研究了SERT和相关信号通路 (NOD2/RIP2/NF-κB) 的表达.
主要成果:
- 在严重骨质疏松症患者中,便LA丰度下降,与骨质疏松症正相关.
- 在老鼠中,LAS补充剂减轻了老年骨质疏松症.
- 拉斯在体外增加了SERT表达,抑制了NOD2/RIP2/NF-κB信号通路.
结论:
- 乳杆菌酸性超 (LAS) 证明了对骨质疏松症的治疗潜力.
- 通过上调SERT表达和抑制促炎信号,LAS可以缓解骨质疏松症.
- 结肠上皮细胞中SERT表达的增加是LAS抗骨质疏松作用的关键机制.
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