在2012-2016年越南北部的Shigella flexneri的特征描述
Dong Tu Nguyen1, Masatomo Morita2, Tuan Cuong Ngo1
1Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Access microbiology
|July 10, 2023
概括
越南Shigella flexneri的遗传特征揭示了两个不同的血统. 一个血统,Sub-1,与血清型1a相关,可能是区域特定的,突出显示出独特的公共卫生问题.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 石病是发展中国家的主要公共卫生问题.
- 在全球范围内,Shigella flexneri和Shigella sonnei是常见的,S. sonnei越来越多地取代了S. flexneri.
- 在越南北部发生了Shigella flexneri疫情,但遗传数据很少.
研究的目的:
- 来自越南北部的Shigella flexneri菌株的遗传特征.
- 了解该地区S. flexneri的遗传多样性和进化关系.
主要方法:
- 从2012年至2016年,对17个S. flexneri分离物进行了全基因组测序.
- 分子血型定型,抗菌素耐药性基因鉴定和集群分析.
- 植物遗传学分析包括先前研究的分离物.
主要成果:
- 所有分离物属于第3类,分为两个子系:第1类 (13个分离物,血清型1a) 和第2类 (4个分离物,血清型2a).
- 亚-1分离物,包括来自延白省疫情的分离物,携带了gtrI基因和菌体元素.
- 在延白省 (2015-2016) 发生的两起事件起源于最近的共同祖先.
结论:
- 在越南北部确定了两个不同的S. flexneri族群3亚系.
- 与血清型1a相关的Sub-1血统可能在地理上是特定于该地区的.
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