菌的分泌体抑制了Mycobacterium tuberculosis复杂菌根菌的生长
Wafaa Achache1,2, Jean Louis Mege1,2, Mustapha Fellag1,2
1Aix-Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France.
Access microbiology
|July 10, 2023
概括
肠道细菌Enterococcus mundtii可以抑制Mycobacterium结核复合体 (MTC) 的生长. 它的分泌体显示出抗结核病的潜力,这表明它在人类和动物健康中起着保护作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 细菌学 细菌学是一门学科.
背景情况:
- 肠球菌 (Enterococcus mundtii) 是一种开始性肠道细菌.
- 一些Mycobacterium结核复合体 (MTC) 种类在人类和哺乳动物中引起结核病.
- 初步观察表明,E. mundtii可以抑制MTC的生长.
研究的目的:
- 调查E. mundtii对MTC物种的抑制作用.
- 为了探索E. mundtii秘密体的抗结核潜力.
主要方法:
- 对五种E. mundtii菌株和七种MTC菌株进行交叉调查.
- 标准化定量阿加尔井扩散试验.
- 分析冷干燥的无细胞培养超浮体 (CFCS).
主要成果:
- 所有五种E. mundtii菌株都在校准的注射器 (10 MacFarland) 上抑制了MTC生长.
- E. mundtii CFCS 抑制了 M. tuberculosis,M. africanum,M. bovis 和 M. canettii 的生长.
- 抑制与CFCS蛋白度成比例.
结论:
- E. mundtii的分泌体抑制了所有医学上相关的MTC物种.
- E. mundtii secretome可能会调节肠道中的结核病表达.
- E. mundtii 具有抗结核作用,并具有潜在的保护作用.
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