有证据表明,英格兰墓地的某些抗菌性质
J A Taylor1, Toscane Fourie2, Mark Powell3
1E.E.E.S and The Graduate School, The Open University, Walton Hall, Milton Keynes MK 7 6AA, UK.
Access microbiology
|July 10, 2023
概括
液体产生的新型抗微生物化合物有效对抗耐药细菌和真菌. 来自Diploicia canescens和Pertusaria amara的提取物显示出强烈的活性,突出了它们在新抗生素开发中的潜力.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 越来越多的抗药性细菌需要新的抗生素来源.
- 虫产生各种各样的,强大的防御化学物质,具有抗微生物潜力.
研究的目的:
- 为了评估十种常见的英国墓地的抗菌性质.
- 为了确定具有显著抗菌和抗真菌活性的类物种.
主要方法:
- 采集了十种鱼物种,并使用原始乙进行提取.
- 对六种细菌和两种真菌进行了磁盘扩散敏感性测试.
- 根据抑制区评估了抗菌活性.
主要成果:
- 从Diploicia canescens,Psilolechia lucida,Lecanora sulphurea,Pertusaria amara和Lepraria incana中提取出来的提取物抑制了格拉姆阳性细菌.
- 迪普洛希亚,佩尔图萨里亚阿玛拉和勒普拉里亚伊卡纳的提取物显示出对皮肤植物的抗真菌活性.
- 勒普拉里亚incana是唯一一种抑制格拉姆阴性Pseudomonas aeruginosa的提取物;Diploicia canescens和Pertusaria amara表现出最强大的整体抗菌活性.
结论:
- 迪普洛希亚 (Diploicia canescens) 和珀图沙里亚 (Pertusaria amara) 的原始提取物显示出显著的抗菌潜力.
- 的提取物,特别是D. canescens和P. amara的提取物,代表了新型抗生素发现的有希望的来源.
- 一个不寻常的发现是,在 Porpidia tuberculosa 的样本中观察到的差异性活性.
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