骨肌肉质量的术后相对下降作为胃癌患者生活质量的预测指标
Yoshinori Ueda1,2, Akiyoshi Seshimo3, Takahiro Okamoto1
1Department of Surgery II, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
Molecular and clinical oncology
|July 10, 2023
概括
胃切除术后骨肌肉质量的显著下降与癌症幸存者的健康和生活质量 (QOL) 差异有关. 监测这种变化 (ΔSMI) 可以帮助评估营养状况并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 康复医学 康复医学 康复医学
背景情况:
- 胃癌手术 (胃切除术) 可以导致骨肌肉量减少,影响患者的康复和生活质量 (QOL).
- 在胃切除术后对骨肌肉质量变化的客观评估对于了解营养状况和功能结果至关重要.
研究的目的:
- 调查骨肌量 (ΔSMI) 的相对变化与胃癌患者的术后感知健康和QOL之间的关联.
- 确定 ΔSMI 是否可以作为胃切除术幸存者的功能状况受损和 QOL 的指标.
主要方法:
- 一项涉及74名患有I-III期胃癌手术后患者的横截面研究.
- 骨肌肉质量指数 (SMI) 使用计算机断层扫描 (CT) 来计算 ΔSMI: (手术前SMI - 手术后SMI) / 手术前SMI x100.
- 评估了健康结果,包括胃切除术后的症状和QOL,使用胃切除术后综合征评估尺度-45 (PGSAS-45).
主要成果:
- 平均 ΔSMI 的值为 8.64%.
- 10%或以上的 ΔSMI 与显著更高的症状评分和较低的一般健康和身体成分总结 (PCS) 评分相关.
- 多变量分析证实,ΔSMI与PCS衰退显著相关 (标准化回归系数=-0.447).
结论:
- 骨肌肉质量 (ΔSMI) 的相对变化与胃切除术后的身体功能降低和QOL显著相关.
- 监测 ΔSMI 可能有助于临床医生客观评估营养状况,并识别患有功能状况受损和 QOL 风险的患者.
- 基于 ΔSMI 的早期识别和干预可能会改善胃切除术幸存者的结果.
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