癌症生物治疗后的眼表面并发症
Kevin Sheng-Kai Ma1,2,3, Ping-Feng Tsai4, Tina Yi-Jin Hsieh5,6
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Frontiers in toxicology
|July 10, 2023
概括
新型癌症疗法,如表皮生长因子受体抑制剂和免疫检查点抑制剂,可以导致严重的眼睛问题. 管理这些不良的角膜事件需要多学科的方法,包括瘤学家和眼科医生.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在过去的20年里,生物制剂彻底改变了癌症治疗.
- 这些新疗法可能会导致意想不到的不良结果,特别是影响角膜.
- 眼部并发症是接受生物治疗的癌症患者的一个新兴问题.
研究的目的:
- 审查与生物癌症疗法相关的不良角膜并发症.
- 讨论这些眼睛表面问题的流行病学,病理生理学和管理.
- 突出不同医学专业之间的协作护理的重要性.
主要方法:
- 对与生物癌症剂相关的角膜不良事件的文献综述.
- 专注于表皮生长因子受体抑制剂和免疫检查点抑制剂.
- 分析报告的眼表面并发症,包括干眼和移植排斥.
主要成果:
- 皮表皮生长因子受体抑制剂和免疫检查点抑制剂经常与角膜不良事件有关.
- 免疫检查点抑制剂与眼睛干燥,史蒂文斯-约翰逊综合征和角膜移植排斥有关.
- 眼球表面并发症在治疗生物癌症治疗的患者中构成了重大挑战.
结论:
- 角膜不良事件是现代生物癌症治疗的显著副作用.
- 有效的管理需要眼科医生,皮肤科医生和瘤科医生之间的密切合作.
- 需要进一步研究这些并发症的病理生理学和治疗方法.
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