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在COVID-19的鼻抽样中对共存的病原体进行分析

Zhan Gao¹, Lisong Yu^2,3, Ling Cao⁴

¹Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China.

Frontiers in cellular and infection microbiology

|July 10, 2023

概括

与细菌的同时感染在COVID-19患者中很常见,增加了并发症风险. 识别这些病原体对于在SARS-CoV-2管理中有效治疗和抗生素管理至关重要.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
基因组学就是基因组学.

背景情况:

COVID-19 (冠状病毒疾病2019) 管理正在进行中,常见的是类似流感的症状.
在SARS-CoV-2感染个体中共存的病原体构成重大风险.
了解共感染对于指导有效的COVID-19治疗策略至关重要.

研究的目的:

为了研究SARS-CoV-2感染患者的共存病原体.
识别危险微生物的多样性和丰富性.
通过了解共感染因素来指导治疗策略.

主要方法:

从COVID-19患者的鼻抽样中提取了总DNA和RNA.
构建了元基因组图书馆,并使用了下一代测序 (NGS).
分析了高通量测序数据,使用克罗纳物种多样性分类方法来分析物种多样性.

主要成果:

识别了威胁性病原体,包括 Mycoplasma pneumoniae,Klebsiella pneumoniae和Streptococcus pneumoniae. 这些病原体可能会导致肺炎.
发现与细菌感染相结合的SARS-CoV-2更为常见.
作为关键的共感染风险,突出显示了肺炎菌株,流感菌株,金黄色菌株,肺炎菌株和人类疹病毒4.

结论:

在COVID-19患者的共同感染和超级感染状态令人担忧.
细菌代表一个主要的威胁群体,增加并发症和死亡风险.
这些发现对于识别和治疗SARS-CoV-2共感染有价值,强调抗生素控制.

关键词:

这就是SARS-CoV-2病毒.同时感染的同时感染.高通量测序的高通量测序转基因组学是指转基因组学.呼吸系统的病原体

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