黄素和肠道微生物群通过肠-大脑轴的神经调节作用
Haoran Wang1,2, Tingting Zhao1,2, Zhenjiang Liu3
1Institute of Animal Husbandry and Veterinary, Tibet Academy of Agricultural and Animal Husbandry Sciences, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lhasa, China.
Frontiers in cellular and infection microbiology
|July 10, 2023
概括
饮食中的黄类化合物可以通过减少氧化应激和炎症来保护大脑. 它们还积极影响肠道细菌,这些细菌通过微生物群-肠道-大脑轴与大脑进行通信.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 饮食中的黄类药物通过直接和间接的机制显示出神经保护的潜力.
- 黄类药物可以穿过血脑屏障 (BBB),并在中枢神经系统 (CNS) 内产生作用.
- 肠道微生物群的代谢物影响大脑功能和宿主行为.
研究的目的:
- 审查目前关于生物活性黄素,肠道微生物群和肠-大脑轴之间的关系的研究.
- 探索黄胺如何调节肠道微生物群的组成和功能.
- 了解微生物群-肠-大脑轴介导的间接神经保护作用.
主要方法:
- 关于黄类药物,神经保护,肠道微生物群和肠-大脑轴的现有研究的文献综述.
- 对中枢神经系统和肠道中黄类药物的作用机制的分析.
- 综合证据,将黄素摄入量与肠道微生物群调节和大脑健康联系起来.
主要成果:
- 黄类药物可以抑制神经炎症和氧化应激反应,促进神经元的生存.
- 黄类药物作为有益的肠道细菌的基质,促进神经保护性代谢物的产生.
- 黄素通过塑造微生物群组成来影响肠-大脑轴,可能抑制病原体.
结论:
- 黄类药物通过直接的中枢神经系统作用和肠-大脑轴的间接调节提供神经保护.
- 用黄类药物准肠道微生物群是改善大脑健康的有希望的策略.
- 需要进一步的研究,以充分阐明饮食,肠道微生物群和神经功能之间的复杂相互作用.
相关概念视频
Physiology of Enteric Nervous System and Gut Health
324
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
324
Enteric Nervous System: Regulation of GI Motor Activity
473
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
473
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
313
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
313
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
160
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
160
Regulation of the Digestive System
703
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
703


