在多次SARS-CoV-2疫苗接种后,免疫功能低下个体的不同细胞和幽默免疫反应
Rhys T Meredith1, Max D Bermingham1, Kirsten Bentley2
1InBio, Cardiff, United Kingdom.
Frontiers in cellular and infection microbiology
|July 10, 2023
概括
免疫功能低下的个体,特别是风湿病患者和移植接受者,对COVID-19的疫苗反应减少. 需要个性化策略来保护弱势群体免受SARS-CoV-2的侵害.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 免疫功能受损的个体往往对疫苗反应不佳,增加了COVID-19的风险.
- 关于这些群体多次SARS-CoV-2疫苗接种的有效性存在相互矛盾的数据.
研究的目的:
- 评估免疫功能低下群体接种疫苗后的幽默和细胞免疫力.
- 为了比较风湿病患者,移植患者和艾滋病毒感染者 (PLWH) 的免疫反应与免疫能力强的对照.
主要方法:
- 测量了细胞因子释放,中和抗体和SARS-CoV-2尖端特定的IgG.
- 分析了来自风湿病患者 (n=29),移植接受者 (n=46),PLWH (n=27) 和对照组 (n=64) 的样本.
主要成果:
- 与对照组相比,风湿病患者和移植患者的IFN-γ,IL-2和中和抗体水平显著降低.
- 在这些群体中,IgG抗体反应也减少了.
- 在PLWH和之前感染过SARS-CoV-2的个体中,细胞或幽默反应没有受损.
结论:
- 特定的免疫受损子组可能需要量身定制的疫苗接种或治疗策略.
- 识别疫苗不响应者对于保护高风险个体至关重要.
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