加勒-8 改变免疫微环境,促进瘤的进展
Yiting Wang1,2, Yufan Sun3, Hai Li1
1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, China.
American journal of cancer research
|July 10, 2023
概括
加勒-8 (Gal-8) 通过增加抑制性免疫细胞和减少CD8+ T细胞来促进瘤免疫抑制. 这一发现突显了Gal-8作为癌症预后和治疗点的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 加勒-8 (Gal-8),由LGALS8基因编码,是一种具有已知的瘤调节功能的加勒家族成员.
- 新兴证据表明,Gal-8有助于调节先天性和适应性免疫力,在瘤和免疫失调疾病中观察到高表达.
研究的目的:
- 阐明加勒-8 (Gal-8) 在诱导瘤免疫抑制中的作用.
- 用动物模型和临床数据分析Gal-8对瘤免疫微环境的影响.
主要方法:
- 在Gal-8表达瘤的动物模型中分析瘤透免疫细胞.
- 在乳腺和结直肠癌的临床样本中评估Gal-8表达.
- 对Gal-8表达与淋巴结转移和免疫类型的相关性分析.
主要成果:
- 表达Gal-8的瘤显示抑制性免疫细胞 (Tregs,MDSCs) 的扩张和CD8+ T细胞的减少.
- 在乳腺和结直肠癌组织中分类了Gal-8表达模式.
- 在癌症中,LGALS8基因表达与透的活性CD8+T细胞和免疫刺激调节器负相关.
结论:
- 加勒-8 (Gal-8) 在调节瘤免疫微环境方面发挥着重要作用,促进免疫抑制.
- -8显示出作为预后生物标志物和癌症治疗的治疗点的潜力.
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