听力障碍与甘油三指数之间的相关性:基于国家横截面研究
Long Liu1, Maolin Qin2, Jiabiao Ji1
1Department Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Frontiers in endocrinology
|July 10, 2023
概括
较高的甘油三糖 (TyG) 指数与听力损伤 (HI) 的风险增加有关. 这种线性关系在高频听力损失中尤为明显,并且在考虑听力敏度的听力福克测试 (HPTA) 时变得更加重要.
科学领域:
- 代谢健康 代谢健康
- 听力学 听力学是指听力学.
- 公共卫生 公共卫生
背景情况:
- 甘油三糖指数 (TyG) 是胰岛素耐药性的标志物.
- 听力障碍 (HI) 是一个越来越严重的公共卫生问题,其原因有多种因素.
- 了解代谢因素和HI之间的关系对于预防策略至关重要.
研究的目的:
- 调查甘油三糖 (TyG) 指数与听力损失 (HI) 风险之间的关联.
- 探索这种关系的性质,包括线性和频率特异效应.
主要方法:
- 采用了2001-2012年和2015-2018年国家健康和营养检查调查 (NHANES) 八个调查周期的数据进行的横截面研究.
- 多重后勤回归和处罚分线/通用添加模型 (GAM) 用于评估TyG指数和HI之间的相关性.
- 进行了子组分析,以确定敏感人群.
主要成果:
- 分析了10906名参与者的队列.
- 在TyG指数和听力损失的频率之间观察到线性正相关性.
- 这种关联在高频率HI (OR = 1.12,95% CI: 1.03,1.22) 中具有统计学意义,但在低频率HI中没有.
- 听力敏度的听力福克测试 (HPTA) 显示了与更严重的HI (OR = 1.14,95% CI: 1.05-1.24) 的积极关联.
结论:
- 提升的TyG指数与听力损失的风险增加有关.
- TyG指数和HI风险之间的关系是线性的,并且随着严重程度的增加而变得更加明显,特别是当考虑HPTA时.
- 亚组分析表明,这种关联在40-69岁的女性中没有高血压或糖尿病,在40-69岁的男性和女性中高血压和糖尿病中更为显著.
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