相关实验视频
Updated: Jul 24, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.7K
在差异化甲状腺癌患者的甲状腺激素戒断期间,甲状腺功能暂时受损
Li-Ying Hou1, Xiao Li2,3, Guo-Qiang Zhang1
1Department of Nuclear Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in endocrinology
|July 10, 2023
概括
在放射性治疗期间的短期甲状腺功能低下会在差异化甲状腺癌患者中暂时损害内皮功能. 这种与LDL变化相关的功能障碍在恢复甲状腺刺激激素抑制疗法后会消失.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 内皮功能障碍是动脉样硬化的早期指标,通常与慢性甲状腺功能低下有关.
- 由于放射性 (RAI) 治疗而停止使用甲状腺素引起的短期甲状腺功能低下症对差异化甲状腺癌 (DTC) 患者内皮功能的影响尚不清楚.
研究的目的:
- 评估RAI治疗期间的短期甲状腺功能低下是否会影响DTC患者的内皮功能.
- 在整个RAI治疗过程中评估相关的代谢变化.
主要方法:
- 招募了51名接受全甲状腺切除术并准备接受RAI治疗的DTC患者.
- 在三个时间点使用流介导扩张 (FMD) 通过超声波测量内皮功能:在甲状腺素取消之前 (P1),在RAI注射之前 (P2) 和RAI后4-6周 (P3).
- 在这些时间点,甲状腺功能和血清脂质水平也被分析.
主要成果:
- 与P1 (P<0.001) 相比,P2的流媒扩张 (FMD) 在P2显著下降 (P<0.001).
- 在恢复甲状腺刺激激素 (TSH) 抑制疗法 (P=0.146) 后,FMD在P3恢复到基线水平.
- 低密度脂蛋白 (LDL) 的变化与治疗期间口炎的变化有负相关性 (P<0.05).
结论:
- 在RAI治疗期间的短期甲状腺功能低下会在DTC患者中暂时损害内皮功能.
- 在恢复TSH抑制治疗后,内皮功能恢复到基线水平.
- 在此期间,低密度脂蛋白水平是与内皮功能变化相关的重要因素.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:23The Thyroid Gland
4.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.0K