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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis
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阿迪波基因调节介质干细胞骨质分化的分化.

Zhong-Hua Xu1, Chen-Wei Xiong2,3, Kai-Song Miao2,3

  • 1Department of Orthopedics, Jintan Hospital Affiliated to Jiangsu University, Changzhou 213200, Jiangsu Province, China.

World journal of stem cells
|July 10, 2023
PubMed
概括

脂肪组织中的信号分子阿迪波金 (adipokines) 在调节介质干细胞 (MSC) 骨质分化的过程中起着至关重要的作用. 本综述强调了它们对组织工程应用的骨形成和再生的影响.

关键词:
艾迪波基因 (Adipokine) 是一种可怕的药物.脂肪组织的脂肪组织.骨再生 骨的再生介质细胞干细胞 介质细胞干细胞骨质发生过程 (osteogenesis)骨质变异的分化是因为骨质变异.

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科学领域:

  • 生物医学工程 生物医学工程
  • 细胞生物学 细胞生物学
  • 内分泌学 在内分泌学.

背景情况:

  • 中介细胞干细胞 (MSCs) 分化为骨,软骨,肌肉和脂肪组织.
  • MSC 的骨质分化是骨组织工程的关键.
  • 阿迪波基因越来越多地被认为对新陈代谢,免疫力和骨质稳定有作用.

研究的目的:

  • 审查adipokines在介质干细胞骨质分化中的作用.
  • 为了强调adipokines在骨形成和再生中的重要性.

主要方法:

  • 对阿迪波金和MSC骨质基因分化研究的文献综述.
  • 分析证据,将阿迪波金与骨形成和再生过程联系起来.

主要成果:

  • 阿迪波基因显著影响MSC骨质性分化途径.
  • 特定的阿迪波金已被确定为骨形成的促进者或抑制者.
  • 了解阿迪波金的作用可以推进骨组织工程策略.

结论:

  • 阿迪波基因是MSC骨质分化的关键调节剂.
  • 向阿迪波金具有提高骨再生疗法的潜力.
  • 对阿迪波金信号通路的进一步研究是治疗开发的必要条件.