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图像研究中心:通向通用尺度和面具,用于标准化图像研究研究
Victor L Villemagne1,2, Antoine Leuzy3, Sandra Sanabria Bohorquez4
1Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Alzheimer's & dementia (Amsterdam, Netherlands)
|July 10, 2023
概括
一个新的通用尺度,CenTauRz,在阿尔茨海默病 (AD) 研究的不同标志物中标准化tau成像. 这种尺度使用了新的特异性皮质面具来准确测量大脑中的沉积物.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 生物标志物开发 生物标志物开发
背景情况:
- 定子发射断层扫描 (PET) 标记物的扩散需要标准化的定量测量.
- 一个通用尺度对于跨研究和中心的一致的tau成像分析至关重要.
研究的目的:
- 开发标准化的tau特异性皮质面膜.
- 为量化图像图像制造创建一个通用尺度.
- 为了在tau PET研究中实现交叉追踪器和交叉中心的可比性.
主要方法:
- 从认知不受损和阿尔茨海默病 (AD) 患者中开发了几种皮质陶氏面具.
- 创建了一个通用面具,不包括已知异目标信号的区域.
- 使用这些面具构建了CentTauRz通用尺度.
- 对1045名参与者施加了口罩和尺度,这些参与者用6种不同的tau标记器进行了扫描.
主要成果:
- 开发的面具有效地隔离了tau信号,排除了目标区域之外的区域.
- 该Centaurz尺度表现出强大的能力,以区分低和高的陶氏存水平.
- 通用尺度为量化病理提供了一种标准化的方法.
结论:
- 针对AD连续性的特异性皮质面具和通用尺度 (CenTauRz) 已被开发出来.
- 这种标准化的方法在各种标记器和研究场所之间促进了一致的tau成像分析.
- 开发的口罩是公开的,以促进更广泛的采用和研究合作.
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