口服降级疗法的临床影响 针对格兰阴性细菌病:一项回顾性研究
Nhi Nguyen1, Ashitha Jayachandran2, Minhhang Mui2
1Ben Taub Hospital, Houston, TX.
HCA healthcare journal of medicine
|July 10, 2023
概括
口服逐步降低治疗格拉姆阴性细菌病是安全和经济有效的. 与仅静脉注射治疗相比,这种方法没有增加30天的死亡率,也没有降低治疗成本.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 越来越多的证据支持口服逐步降低治疗格兰阴性细菌血症.
- 住院患有格拉姆阴性细菌病的患者通常只接受静脉注射 (IV) 治疗.
- 口服降级疗法使用具有不同生物可用性的抗微生物药物.
研究的目的:
- 为了比较IV-only治疗与口服逐步降低疗法对格兰阴性细菌病的结果.
- 评估抗微生物生物可用性对治疗疗效的影响.
- 评估死亡率,复发,并发症和成本效益.
主要方法:
- 回顾性,单中心,观察性研究.
- 包括199名成年患者入院,患有格拉姆阴性细菌血症.
- 从电子病历和临床监测系统中收集的数据.
主要成果:
- 口服降级疗法组的30天全因死亡率显著降低 (P < .0001).
- 在30天的细菌性病复发,线相关并发症或住院时间方面没有显著差异.
- 口服降级疗法与显著降低抗生素成本有关 (P < .00001).
结论:
- 口服逐步降低疗法是一种安全的替代方案,用于仅IV治疗的gram阴性细菌.
- 口服降级疗法更具成本效益,而不会影响患者的治疗结果.
- 进一步的研究可能会探索口服逐步降低方案的最佳抗微生物选择.
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