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在患有渐进性角膜的患者中,角膜交叉连接后长期角膜平

Maria A Henriquez¹, Lisett Perez¹, Gustavo Hernandez-Sahagun¹

¹Research Department, Oftalmosalud Institute of Eyes, Lima, Perú.

Clinical ophthalmology (Auckland, N.Z.)

|July 10, 2023

概括

角膜交叉连接 (CXL) 有效地阻止长期的渐进性角质 (KC). 虽然通常是安全的,但有些患者可能会经历极端的角膜平,可能会影响视力.

科学领域:

眼科医生眼科眼科
角膜外科手术角膜外科手术
视觉科学科学视觉科学

背景情况:

角膜 (KC) 是一种渐进的角膜脱光症,导致视力受损.
角膜交叉连接 (CXL) 是一种标准的治疗方法,可以阻止KC的进展.
长期CXL的结果,特别是在极端角膜平整方面,需要进一步研究.

研究的目的:

评估长期视觉,折射和角膜交叉连接 (CXL) 的角膜交叉连接在进展性角膜 (KC) 的患者中的角膜交叉连接 (CXL).
为了确定CXL后极端角膜平的发生率.
评估CXL在十年或更长的时间内管理渐进式KC的安全性和有效性.

主要方法:

一个追溯的队列研究,对45只眼睛进行了CXL,并切除了上皮质.
在手术前收集的数据,在1年后收集的数据,以及手术后至少10年的数据.
结果措施包括视敏度 (UDVA,CDVA),角膜测量 (Ks) 和Scheimpflug成像;进展定义为Ks增加≥1.5D;极端平作为K减少≥5D.

主要成果:

平均随访时间为11年;观察到Ks,UCVA,CDVA和球体等效的显著改善.
整体的KC进展率很低,为2.22%.
15.5%的眼睛出现了极度平整,其中4.44%的眼睛出现了CDVA损失;由于严重的平整,一个病例需要角膜移植.

结论:

角膜交叉连接 (CXL) 是一种安全有效的长期治疗渐进性角膜 (KC) 的方法.
极端角膜平是一种潜在的,尽管不常见的CXL并发症,可能导致显著的视力丧失.
眼科医生应该意识到严重角膜平整的可能性及其CXL后的视觉后果.

关键词:

在CXL CXL中.交叉连接交叉连接交叉连接形 (keratoconus) 是一种形.克拉图度平面化 (keratometric flattening) 是一种方法来平整一个区域.

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