肺腺癌患者表皮生长因子受体突变特征和吸烟模式之间的关系:一个横截面研究
Seyedeh Yasamin Parvar1, Alireza Rezvani2, Rezvan Ghaderpanah1
1Student Research Committee Shiraz University of Medical Sciences Shiraz Iran.
Health science reports
|July 10, 2023
概括
表皮生长因子受体 (EGFR) 突变与非小细胞肺癌 (NSCLC) 的吸烟模式有关. 这项研究在25.3%的患者中发现了EGFR突变,女性非吸烟者的患病率更高,但在男性吸烟者中也注意到了它们的存在.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 非小细胞肺癌 (NSCLC) 是最常见的肺癌类型,吸烟是主要的风险因素.
- 表皮生长因子受体 (EGFR) 突变是NSCLC向治疗的关键生物标志物,显著改善了患者的治疗结果.
- 了解EGFR突变与患者人口统计学,特别是吸烟习惯之间的相关性,对于完善治疗策略至关重要.
研究的目的:
- 在被诊断为肺腺癌的患者中调查EGFR突变与吸烟模式之间的关联.
- 分析影响NSCLC患者EGFR突变存在的人口和吸烟相关因素.
主要方法:
- 一项涉及217名18岁以上NSCLC患者的横截面研究.
- 使用聚合酶链反应和桑格测序分析了EGFR基因突变 (18-21的外显子).
- 统计分析包括后勤回归,奇二次测试和曼-惠特尼U测试来评估相关性.
主要成果:
- 在25.3%的NSCLC患者中检测到EGFR突变,其中19个外基因的缺失是最常见的 (61.8%).
- 大多数EGFR突变患者是非吸烟者 (81.8%) 和女性 (52.7%).
- 与野生型组相比,在突变EGFR组中观察到较低的中位吸烟持续时间和包装年. 女性性别,当前和重度吸烟与EGFR突变有显著的相关性 (p<0.05).
结论:
- 女性性别和非吸烟者身份与NSCLC的EGFR突变密切相关.
- 与传统建议相反,在男性患者和吸烟者中观察到显著的EGFR突变患病率,支持所有NSCLC患者的常规检测.
- 关于EGFR突变模式的流行病学数据可以指导治疗决策,特别是在测试访问有限的地区.
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