主要和次要免疫缺陷中的免疫球蛋白替代疗法的实践:马来西亚的一个单一中心的经验
Nurul Hidayah Zahari1, Intan Juliana Abd Hamid2, Sharifah Azdiana Tuan Din1
1Department of Clinical Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
The Malaysian journal of medical sciences : MJMS
|July 10, 2023
概括
静脉注射免疫球蛋白 (IVIG) 的使用因临床指示和患者组而异. 需要国家指导方针,以确保适当的IVIG处方,以获得最佳的患者结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 临床药房 临床药房
背景情况:
- 全球对静脉注射免疫球蛋白 (IVIG) 替代疗法的需求正在上升.
- 了解IVIG使用模式对于资源管理和临床实践至关重要.
- 本研究考察了吉隆坡吉隆坡医院IVIG利用特征和影响因素.
研究的目的:
- 分析吉隆坡医院IVIG使用的特点.
- 为了确定与IVIG管理频率相关的因素.
- 提供支持制定国家IVIG处方指南的数据.
主要方法:
- 追溯的横截面研究设计.
- 从药房部门的IVIG申请表中收集的数据 (2018年1月 - 2019年12月).
- 统计分析包括基平方和t测试;P<0.05被认为是显著的.
主要成果:
- 482名患者接受了IVIG;中位数年龄27岁.
- 最常见的适应症包括:低血糖球蛋白血症 (26.3%),川崎病 (儿科,20.3%),慢性炎症性脱髓化多神经病 (成人23.4%),败血症 (儿科31.1%).
- 临床类别与成人 (P=0.004) 和儿科 (P=0.017) 的IVIG频率显著相关.
结论:
- 成人和儿科患者之间,一次性IVIG治疗与常规IVIG治疗的指示存在显著差异.
- 迫切需要对IVIG处方制定国家指南.
- 适当的IVIG处方可以优化患者护理和资源配置.
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