对生物假体门的新型传单几何学的生物机械分析
Pearly K Pandya1,2, Matthew H Park1,2, Yuanjia Zhu1,3
1Department of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
JTCVS open
|July 10, 2023
概括
修改生物假体心脏门以包括更多的叶片,例如四叶形设计,可以显著减少压力,并可能提高耐用性,为先进的门置换疗法提供了一个有前途的途径.
科学领域:
- 生物医学工程 生物医学工程
- 计算力学 计算力学 计算力学
- 心血管器械 心血管器械
背景情况:
- 生物假体门提供良好的血液动力学,但受到有限的耐用性和高的重新操作率的影响.
- 目前的生物假体门普遍采用三叶形设计.
研究的目的:
- 为了研究改变生物假体门中叶片数量的生物力学影响.
- 评估是否有超过三张传单的设计可以提高门的性能和耐用性.
主要方法:
- 生物假体门的in silico设计,使用2到6个小册子,使用二进制线条几何.
- 使用Abaqus CAE软件对小册子应力进行有限元分析 (FEA).
- 评估·米塞斯应力在门关闭期间在大动脉和心交位置.
主要成果:
- 增加小册子数量降低了最大·米塞斯压力;四片小册子设计比三片小册子降低了36% (大动脉) 和38% (心脏) 的压力.
- 最大应力显示与传单数量的平方的反向关系.
- 表面积线性增加,而中央泄漏量则随着传单数量的增加而以二进制的方式增加.
结论:
- 四叶片生物假肢设计可减少叶片应力,同时最小影响表面积和中心泄漏.
- 调节小册子号码为优化生物假体门设计以提高耐用性提供了一个可行的策略.
- 这种方法可能会提高门置换生物假体的寿命.
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