雌激素受体α在衰老和慢性疾病中的作用
José V V Isola1, Sunghwan Ko2, Sarah R Ocañas2,3
1Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Advances in geriatric medicine and research
|July 10, 2023
概括
雌激素受体α (ERα) 的激活有利于新陈代谢,并减少衰老期间的炎症. 组织特异性ERα激动因子可能为与年龄相关的疾病提供治疗潜力,准大脑和肝脏.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究 研究 代谢研究
- 生物老龄化生物学
背景情况:
- 雌激素受体α (ERα) 对于生殖功能至关重要,并调节哺乳动物的代谢和炎症过程.
- 衰老过程中ERα信号的丧失与伴随疾病有关,特别是在更年期的女性中.
- 在避免女性化效应的情况下,ERα激动性可能有利于男性.
研究的目的:
- 审查ERα在大脑和肝脏中关于衰老,新陈代谢和炎症的作用.
- 探索组织特异性ERα激动因子对与年龄有关的疾病的治疗潜力.
- 提出17α-雌激醇作为ERα向治疗的概念证明.
主要方法:
- 文献综述侧重于ERα在衰老,新陈代谢和炎症中的功能.
- 分析证据,将大脑和肝脏中的ERα活性与健康益处联系起来.
- 讨论涉及17α-雌激醇和ERα依赖的研究.
主要成果:
- 大脑和肝脏中的ERα调解了雌激素对代谢和衰老过程中的炎症的有益作用.
- 通过依赖ERα的机制,17α-雌激醇的使用显示出健康益处.
- 证据支持ERα作为缓解衰老和慢性疾病的可用药物点.
结论:
- 在维持新陈代谢平衡和在衰老过程中控制炎症方面,ERα起着至关重要的作用.
- 针对ERα,特别是在大脑和肝脏,为与年龄相关的疾病提供了一个有前途的治疗策略.
- 组织特异性ERα激动性是一种潜在的方法,可以在没有不良影响的情况下对抗衰老和相关疾病.
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