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基因组和生态因素塑造了整个亚科的专业主义和一般主义
Dana A Opulente1, Abigail Leavitt LaBella2, Marie-Claire Harrison3
1Laboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI 53726, USA; Biology Department Villanova University, Villanova, PA 19085, USA.
bioRxiv : the preprint server for biology
|July 10, 2023
概括
微生物利基范围,从专家到全科医生,主要是由与代谢途径相关的内在遗传因素驱动的,而不是性能权衡或外部生态影响.
科学领域:
- 微生物生态学 微生物生态学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 代谢工程是代谢工程.
背景情况:
- 生物体表现出不同的生态利基宽度,从狭窄利基的专家到广泛利基的通用主义者.
- 现有的理论提出了性能和利基范围之间的权衡,或内在/外在因素,以解释这种变化.
研究的目的:
- 研究真菌亚属Saccharomycotina的利基宽度变化的进化驱动因素.
- 确定内在遗传因素,性能权衡和外部生态因素对利基范围的相对贡献.
主要方法:
- 收集了几乎所有已知的Saccharomycotina物种的综合基因组,代谢和生态数据.
- 利用24个条件的定量增长数据进行代谢分析.
- 分析了环境本体学数据来描述生态利基.
主要成果:
- 在Saccharomycotina中确定了碳幅的显著跨物种变化.
- 发现代谢途径的内在遗传差异是利基范围变化的主要来源.
- 没有发现证据支持性能效率和利基范围之间的权衡.
- 结论:外部生态因素在推动利基范围的变化方面发挥着有限的作用.
结论:
- 内在的遗传因素,特别是编码代谢途径的基因,是微生物利基宽度的主要决定因素.
- 在Saccharomycotina中,利基范围的演变主要是由内部生物特征而不是外部环境压力或性能限制所塑造的.
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