认知储备在ALS:职业技能和要求的作用
medRxiv : the preprint server for health sciences
|July 10, 2023
概括
职业病史会影响肌缩侧面硬化症 (ALS) 的认知和运动功能. 具有复杂认知需求的工作可能会防止认知能力下降,但运动储备并没有在ALS患者中对运动功能障碍产生保护作用.
科学领域:
- 神经科学是一个神经科学.
- 职业健康 职业健康 职业健康
- 神经学 神经学
背景情况:
- 肌缩侧面硬化 (ALS) 是一种复杂的神经退行性疾病,具有多种运动和认知症状.
- 认知储备 (CR) 和运动储备 (MR) 假设表明,职业复杂性可能会影响疾病的进展.
研究的目的:
- 研究ALS患者的职业病史和认知/运动功能之间的关联.
- 测试认知储备 (CR) 是否可以防止认知衰退,运动储备 (MR) 是否可以防止ALS的运动功能障碍.
主要方法:
- 使用爱丁堡认知和行为ALS屏幕 (ECAS) 和运动秤 (PUMNS,ALSFRS-R) 评估了150名ALS患者.
- 职业信息网络 (O*NET) 数据库被用来量化工作特征.
- 多重线性回归分析了职业因素和临床结果之间的关系.
主要成果:
- 具有更高推理,社会能力,分析能力和人文知识的职位与更好的ECAS分数 (认知功能) 有关.
- 对环境危害的暴露和在工作中的技术技能与较低的ECAS分数相关.
- 与运动相关的职业因素对运动功能没有显著的保护作用;精确技能与较差的运动结果有关.
结论:
- 职业史,特别是认知复杂性,与ALS的认知功能保持有关,支持CR假设.
- 没有证据表明运动储备 (MR) 可以防止ALS的运动衰退.
- 职业因素突出了潜在的保护和风险因素,影响了ALS的认知和运动变异性.
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