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Updated: Jun 13, 2026

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在Fab方法上的结构约束不足,而不是帕拉托普诱导限制了HIV-1MPER疫苗的实用性

Kemin Tan, Junjian Chen, Yu Kaku

    bioRxiv : the preprint server for biology
    |July 10, 2023
    PubMed
    概括

    针对MPER/脂质体构造的HIV-1 gp41膜近接外部区域 (MPER) 的疫苗可以引起抗体,但不能广泛中和抗体 (bnAbs). B细胞编程需要考虑gp160ectodomain,以便使MPER访问.

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    Inhibitors of Virion Maturation and Assembly01:19

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    As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...