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Chronic Salmonella Infection Induced Intestinal Fibrosis
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一种共生细菌对铁的获取在沙门氏菌感染期间改变了宿主营养免疫力
bioRxiv : the preprint server for biology
|July 10, 2023
概括
肠道细菌,如 Bacteroides thetaiotaomicron 使用 siderophores 在炎症期间获得铁. 这一过程对病原体沙门氏菌产生影响.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 营养免疫力 营养免疫力
背景情况:
- 宿主营养免疫力在肠道炎症期间限制微生物铁的获取.
- 病原体利用 siderophores 清理铁,由宿主 lipocalin-2 对抗.
- 开始性细菌在铁介导营养免疫中的作用尚不清楚.
结论:
- 由XusB介导的体内铁代谢是肠道炎症期间宿主-病原体相互作用的新型因素.
- 这突出了影响营养免疫力学动态的未知的机制.
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