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RNF185对COL3A1表达的控制限制了前列腺癌的迁移和转移潜力

Benjamin Van Espen, Htoo Zarni Oo, Colin Collins

bioRxiv : the preprint server for biology

|July 10, 2023

概括

RNF185 (RING指蛋白185) 在前列腺癌中起到瘤抑制作用. 它的耗尽增强了癌细胞的迁移和转移,部分原因是增加了COL3A1的可用性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

RNF185 (RING指纹蛋白185) 是一种参与ER相关降解的泛素酶.
在患者数据中,RNF185表达与前列腺癌进展和转移相反相关.
前列腺癌细胞系在RNF185枯竭后显示出增加的迁移和入侵.

结论:

RNF185作为前列腺癌转移的抑制剂.
RNF185调节癌细胞迁移和入侵,部分通过控制COL3A1水平.
准RNF185或COL3A1可能为前列腺癌转移提供治疗策略.

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