在患有代谢综合征的成年人中,生活方式,左心房结构和功能以及认知能力下降
Ines Gonzalez Casanova1, Ángel M Alonso-Gómez2,3, Dora Romaguera3,4
1Department of Applied Health Science, Indiana University Bloomington School of Public Health, Bloomington, IN, USA.
medRxiv : the preprint server for health sciences
|July 10, 2023
概括
这项研究调查了左心房结构和功能是否调解生活方式因素 (饮食,体育活动,体重) 和认知功能之间的联系. 研究人员没有发现证据支持这种调解途径在超重或肥胖的个体.
科学领域:
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
- 生活方式 医学 医疗
背景情况:
- 饮食,体力活动和体重等生活方式因素与认知功能有关.
- 介导途径,特别是心血管因素,仍然不清楚.
- 健康的生活方式与改善左心房结构和功能相关,这与更好的认知有关.
研究的目的:
- 测试左心房结构和功能调解生活方式因素与认知功能之间的关联的假设.
- 探索潜在的心血管路径,将生活方式和认知联系起来.
主要方法:
- 476名患有超重/肥胖和代谢综合征的参与者接受了生活方式评估和心声回声.
- The Trail Making A测试测量了基线和两年后续的执行功能.
- 调解分析检查了左心房测量是否与生活方式因素 (遵守地中海饮食,身体活动,体重) 与认知功能变化有关.
主要成果:
- 没有发现生活方式因素与Trail Making A测试成绩的变化之间有显著的关联.
- 没有发现间接影响,这表明左心房结构和功能并没有调解这一队列中的生活方式-认知关系.
- 这项研究受到适度样本大小的限制.
结论:
- 左心房的结构和功能似乎并不介导地中海饮食,体力活动,体重和执行功能之间的关系.
- 需要进行更大规模的研究,以调查可能调解生活方式-认知关系的其他潜在心血管因素.
- 需要进一步的研究来充分阐明连接生活方式和认知健康的复杂途径.
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