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病毒基因组的进化潜力来自与人类APOBEC3酶的相互作用

Brenda Delamonica¹, Liliana Davalos², Mani Larijani³

¹Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, 11794, USA.

bioRxiv : the preprint server for biology

|July 10, 2023

概括

由于APOBEC3酶的活性,Mpox病毒 (MPXV) 显示出人类未来进化的高潜力. 了解这些APOBEC3驱动的突变对于疫苗开发和控制mopox传播至关重要.

科学领域:

病毒学病毒学
基因组学就是基因组学.
进化生物学进化生物学

背景情况:

通过诱导突变,APOBEC3酶对宿主防御病毒至关重要.
马波克斯病毒 (MPXV) 爆发显示C>T突变,表明APOBEC3参与.
在APOBEC3压力下MPXV的进化轨迹尚不清楚.

研究的目的:

分析POX病毒基因组中的APOBEC3驱动的进化,重点是MPXV.
预测MPXV在人类人口中的未来突变潜力.
为疫苗开发和疾病制策略提供信息.

主要方法:

在软体动物传染性病毒,疹病毒和MPXV基因组中分析APOBEC3介导的突变模式.
在同名站点测量热点的不足和枯竭.
通过对不同类型的天花病毒的APOBEC3特征进行基因组比较分析.

主要成果:

MPXV表现出明显的APOBEC3突变模式,包括TC热点的过度代表和GC热点的不足代表.
虫传染性病毒与人类的APOBEC3表现出广泛的共同进化,而麻疹病毒则表现出中间特征.
MPXV的基因组特征,如反转的终端重复区域和更长的基因,表明未来APOBEC3介导进化的潜力更高.

结论:

MPXV的突变特征表明,它可以适应具有特定APOBEC偏好的宿主.
该病毒具有特征,使其易于在人类中发生显著的APOBEC3驱动进化.
建议紧急制mopox传播,并进行进一步的生态研究.

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