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Updated: Jul 24, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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纳入物理来克服蛋白质功能的预测建模中的数据稀缺:BK通道的案例研究

Erik Nordquist1, Guohui Zhang2, Shrishti Barethiya1

  • 1Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, USA.

bioRxiv : the preprint server for biology
|July 10, 2023
PubMed
概括

这项研究结合了物理和机器学习来预测大 (BK) 通道电压门,克服数据稀缺. 该模型准确地预测了突变效应,揭示了关键的物理原理,如疏水性门.

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