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鉴定G3BP驱动的压力颗粒形成的小分子抑制剂

Brian D Freibaum1, James Messing1, Haruko Nakamura1

  • 1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

bioRxiv : the preprint server for biology
|July 10, 2023
PubMed
概括

新的小分子,G3BP抑制剂a和b,通过准G3BP1/2蛋白质,有效地抑制和溶解压力颗粒. 这些化合物是研究压力颗粒生物学和潜在治疗方法的宝贵工具.

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