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产前暴露与儿童时期的肠道微生物组有负面关联

Shoshannah Eggers^1,2, Vishal Midya¹, Moira Bixby¹

¹Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in microbiology

|July 10, 2023

概括

产前暴露与儿童肠道微生物组 (GM) 的改变有关. 这项研究发现,怀孕期间母亲血液中含量与9-11岁儿童的转基因成分和功能之间存在负相关性.

科学领域:

环境健康环境健康
微生物组研究微生物组研究
发育毒理学发展毒理学

背景情况:

包括 (Pb) 在内的金属暴露越来越多地被认为对肠道微生物组 (GM) 组成和功能产生影响.
暴露在早期发育过程中,特别是产前,可能对转基因有持久的影响.
了解产前金属暴露与转基因之间的关系至关重要,因为转基因在各种不良健康结果中的作用至关重要.

研究的目的:

研究9-11岁儿童产前 (Pb) 暴露与肠道微生物组 (GM) 之间的关联.
为了确定与产前Pb暴露相关的转基因成分和功能的特定变化.

主要方法:

利用了来自墨西哥城肥胖,生长,环境和社会压力因素 (PROGRESS) 队列的编程研究数据.
在第二和第三个三个月的母亲血液中测量了产前Pb度.
使用元基因组测序分析儿童便样本,并采用多种统计模型 (线性回归,PERMANOVA,WQS回归) 来评估转基因关联.

主要成果:

在产前母亲血液中的Pb水平和9-11岁儿童的GM之间观察到一致的负相关性.
这种负面关联在对α和β多样性的测量,微生物组混合分析和个体种群的测量中是明显的.
重量定量总和 (WQS) 回归表明,产前Pb暴露与肠道微生物群之间存在负相关性,例如*Ruminococcus gnavus*和*Bifidobacterium longum*等特定种群具有显著的相关性.

结论:

试点数据表明,产前暴露与儿童后期肠道微生物组之间存在负面关联.
需要进一步的研究来证实这些发现,并阐明潜在的机制.

关键词:

环境流行病学环境流行病学人类微生物组的人类微生物组母婴健康母婴健康暴露于金属中的金属暴露.权重定量总和回归方法权重定量总和回归

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