微生物组多样性和细胞因子表达的调节在衰老过程中受到性别依赖的方式的影响
Sarah E Webster1, Duncan Vos2, Thomas L Rothstein1
1Center for Immunobiology, Department of Investigative Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
Frontiers in microbiomes
|July 10, 2023
概括
老龄化改变了小鼠的肠道微生物组和免疫系统,性行为起到了关键作用. 这些变化涉及特定的细胞因子和B-1细胞,突出了影响健康的复杂相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 老年学是指老年学的学科.
背景情况:
- 肠道微生物群和免疫系统相互作用,影响宿主健康和疾病,特别是在衰老中.
- 衰老与肠道微生物群的变化有关,但性别和住房位置的影响尚未完全理解.
- 了解这些因素对于解决癌症,自身免疫系统疾病和感染等与年龄相关的疾病至关重要.
研究的目的:
- 研究生物性别,衰老和住房位置在塑造肠道微生物组合中的作用.
- 探索肠道微生物组变化与老年小鼠血清细胞因子概况之间的关系.
- 检查免疫细胞,细胞因子和肠道微生物群在衰老中的相互作用.
主要方法:
- 在两个位置的老龄化雄性和雌性BALB/cByJ小鼠.
- 便样本的16S rRNA基因测序用于微生物组分析.
- 测量血清细胞因子水平和分析B-1细胞信号通路.
主要成果:
- 微生物组组成受到年龄和性别的显著影响,而位置的影响很小.
- 与衰老相关的微生物组变化与细胞因子IL-10和IL-6的血清水平变化相关.
- 发现IL-10和IL-6可以调节CD5+B-1细胞中的pSTAT-3表达,从而影响微生物组的调节.
- 在特定的细胞因子水平和丰富的微生物种群之间观察到显著的相关性.
结论:
- 老年小鼠在肠道微生物组和明显的细胞因子配置中表现出与性别相关的变化.
- 在B-1细胞和肠道微生物群之间存在着显著的,受年龄影响的,取决于性别的相互作用.
- 这些发现揭示了性别,衰老,免疫力,位置和肠道微生物组之间的复杂关系.
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