塞尔德克斯甲基化物/德克斯甲基化物对注意力缺陷/多动症儿童睡眠的影响
Greg W Mattingly1, Ann C Childress2, Andrew J Cutler3,4
1Washington University School of Medicine, Midwest Research Group, St. Louis, MO, United States.
Frontiers in psychiatry
|July 10, 2023
概括
服用塞尔德克斯甲基化物/德克斯甲基化物 (SDX/d-MPH) 的ADHD儿童的睡眠行为有所改善. 大多数睡眠领域在一个月内得到改善,并持续治疗长达12个月.
科学领域:
- 儿科神经学 儿科神经学
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在被诊断为注意力缺陷/多动症障碍 (ADHD) 的儿童中,睡眠障碍很普遍.
- 通常用于ADHD治疗的兴奋剂药物可以作为副作用呈现睡眠障碍.
- 塞尔德克斯甲基化物/德克斯甲基化物 (SDX/d-MPH) 是一种已批准的每天一次口服治疗6岁及以上患者的多动症.
研究的目的:
- 评估SDX/d-MPH治疗期间ADHD儿童的睡眠行为变化.
- 用儿童睡眠习惯问卷 (CSHQ) 分析SDX/d-MPH对特定睡眠领域的影响.
主要方法:
- 一项为期12个月的开放性,剂量优化的安全性研究 (NCT03460652) 包括238名患有多动症的儿童 (6-12岁).
- 使用CSHQ评估了睡眠行为,评估了8个领域:睡前抵抗,睡眠开始延迟,睡眠持续时间,睡眠焦虑,夜间醒来,睡眠障碍,睡眠呼吸障碍和白天嗜睡.
- 一个特异后分析检查了从基线到SDX/d-MPH治疗12个月的个体CSHQ睡眠领域的变化.
主要成果:
- 平均CSHQ总睡眠障碍得分从基线 (53.4) 显著下降到1个月后的50.5,在12个月后持续改善 (p < 0.0001).
- 在8个CSHQ领域中,在5个领域观察到统计学上显著的改善:睡前抵抗,睡眠焦虑,夜间醒来,睡眠障碍和白天嗜睡.
- 偏睡症和白天嗜睡症显示出最实质性的改善. 睡眠开始延迟得分显著增加,而睡眠持续时间和睡眠呼吸障碍没有显著恶化.
结论:
- 在ADHD儿童中使用SDX/d-MPH治疗并没有导致整体睡眠障碍的恶化.
- 经过一个月的治疗后,在多个睡眠领域出现了显著的改善,并在整个12个月的研究期间保持.
- SDX/d-MPH在儿童多动症患者的睡眠行为各方面的积极影响.
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