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Updated: Aug 11, 2026

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过度表达的FOXM1与MMB合作,增加NSCLC中WEE1抑制剂的敏感性

Jian Tan1, Jingbo Ma1, Weiqiang Zhang1

  • 1Department of Thoracic Surgery, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.

Journal of thoracic disease
|July 10, 2023
PubMed
概括

叉头盒M1 (FOXM1) 和MYB-MuvB复合体 (MMB) 的相互作用增强了非小细胞肺癌 (NSCLC) 中对WEE1抑制剂的敏感性. 这种FOXM1-MMB复合物促进DNA复制应激并激活检查点,为NSCLC提供新的治疗策略.

关键词:
叉头盒子M1 (FOXM1) 的位置.MYB-MuvB复合体 (MMB) 是一个复合体.类似Wee1的蛋白激酶 (WEE1)非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.

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