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在具有固体成分的肺腺癌中,PD-L1表达和分子异常之间的关系

Kun Zhu^1,2, Yining Zou^1,3, Li Zhao¹

¹Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of thoracic disease

|July 10, 2023

概括

在具有固体成分的肺腺癌 (LUAD-SC) 中,高编程细胞死亡配体1 (PD-L1) 表达与晚期和特定突变相关. 在活检和切割样本中评估固体成分可以识别高PD-L1表达病例.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

之前的研究探讨了编程细胞死亡配体1 (PD-L1) 表达和肺腺癌 (LUAD) 的遗传突变.
对于中国的固体成分LUAD患者 (LUAD-SC) 存在有限的大规模研究.
活检与切除样本中的PD-L1表达相关性的一致性尚不清楚.

研究的目的:

调查在LUAD-SC.中PD-L1表达的临床病理特征和遗传相关性.
为了比较活检和切割样本之间的PD-L1表达模式.
为了确定PD-L1表达在LUAD-SC.中的预后值.

主要方法:

分析了1186个LUAD-SC标本,根据PD-L1瘤比例得分 (TPS) 分类.
评估突变信息,临床病理特征和驱动基因变异.
在活检 (n=96) 和切除 (n=1,090) 标本中的PD-L1表达的比较.

主要成果:

在切除的LUAD-SC中,高PD-L1表达与固体成分,淋巴血管入侵和高级TNM阶段相关.
PD-L1水平与EGFR,KRAS,BRAF突变和ROS1融合有显著的相关性.
与切除的样本相比,活检样本显示出与固体占主导地位,高级TNM阶段和高PD-L1表达的关联.

结论:

在LUAD-SC中高PD-L1表达与明显的临床病理特征和驱动突变有关.
在活检和切割样本中评估固体成分对于识别高PD-L1表达至关重要.
高PD-L1表达是LUAD-SC.中整体存活期的不良预后因素.

关键词:

肺腺癌 (LUAD) 是一种肺腺癌.临床病理学临床病理学突变是一种突变.编程细胞死亡连接物1 (PD-L1)

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