使用修改的Caprini风险评估模型在肺癌中进行术后静脉血栓栓塞的风险评估
Yao Ding1,2, Lijun Yao1, Tao Tan3
1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal of thoracic disease
|July 10, 2023
概括
肺癌患者的术后静脉血栓栓塞 (VTE) 风险很高. 将修改的Caprini风险评估模型 (RAM) 与血红蛋白和D-二次数水平相结合,可以改善切除后的静脉瘤预测.
科学领域:
- 胸部外科手术 胸部外科手术
- 在瘤学瘤学.
- 血管医学 血管医学
背景情况:
- 手术后静脉血栓栓塞 (VTE) 是肺癌患者发病和死亡的重要原因.
- 目前在这个人群中对VTE的风险识别方法有限.
- 准确的风险评估对于有效的VTE预防策略至关重要.
研究的目的:
- 在接受肺癌切除的患者中分析与VTE相关的风险因素.
- 评估修改的卡普里尼风险评估模型 (RAM) 对VTE的预测性能.
- 探索将修改的卡普里尼RAM与特定生物标志物相结合的实用性,以提高VTE预测.
主要方法:
- 针对可切除肺癌患者的前性单中心研究.
- 后勤回归分析以确定VTE风险因素.
- 接收器操作特征 (ROC) 曲线分析,以评估修改后的Caprini RAM的预测能力.
主要成果:
- 静脉瘤发作的发生率为10.5%.
- 年龄,D-二次数,血红蛋白 (Hb),出血和卧床是重要的静脉动脉突发症风险因素.
- 单独修改的Caprini RAM显示出有限的预测值,但其与Hb和D-二次体的组合产生了0.822的AUC (P<0.001).
结论:
- 修改的卡普里尼RAM风险分层在这个队列中对肺切除后的VTE预测不太准确.
- 将修改的Caprini RAM与Hb和D-二次数水平相结合,证明了在接受切除的肺癌患者中对静脉瘤预测的强有力的诊断性能.
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