情绪障碍与OSA慢性失眠患者的自主神经功能相关
Yahui Wan1, Mengdi Lv2, Kaili Zhou1
1Departments of Neurology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, 300308, People's Republic of China.
Nature and science of sleep
|July 10, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 在慢性失眠 (CI) 患者中加剧睡眠问题和自主神经系统 (ANS) 功能障碍. ANS功能障碍可能会导致OSA的CI患者的情绪问题.
科学领域:
- 睡眠医学 睡眠医学
- 自主神经系统研究 自主神经系统研究
- 神经心理学 神经心理学
背景情况:
- 慢性失眠 (CI) 和阻塞性睡眠呼吸暂停 (OSA) 是常见的睡眠障碍.
- 睡眠微观结构,自主神经系统 (ANS) 活动和伴随性CI和OSA患者的神经心理状态之间的相互作用尚未完全理解.
研究的目的:
- 研究慢性失眠和阻塞性睡眠呼吸暂停 (CI-OSA) 患者的睡眠微观结构,ANS活动和神经心理特征之间的相关性.
主要方法:
- 一项涉及45名CI-OSA患者,46名CI患者和22名健康对照者的研究.
- CI-OSA患者被分为轻度和中度至重度OSA组.
- 使用神经心理测试 (HAMD,HAMA,PSQI,ISI,ESS,MMSE) 和多睡眠测试 (PSM-100A) 来评估参与者.
主要成果:
- 与CI患者和HC患者相比,CI-OSA患者的睡眠质量明显降低,白天嗜睡增加,抑郁/焦虑得分更高.
- CI-OSA患者表现出睡眠微观结构的改变,稳定和REM睡眠减少,不稳定睡眠增加.
- 在CI-OSA患者中观察到交感活动升高 (较高的LF和LF/HF比率) 和降低的副交感活动 (较低的HF和Pnn50%比率).
- 在CI-OSA患者中,较高的抑郁和焦虑得分与较差的认知功能和改变的ANS活动相关.
结论:
- 阻塞性睡眠呼吸暂停会加剧慢性失眠患者的睡眠微观结构异常和自主神经系统功能障碍.
- 自主神经系统功能障碍似乎在OSA的CI患者中观察到的情绪恶化中起作用.
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